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Evoluent VerticalMouse 4 review

Evoluent's wired vertical mouse for medium to large hands, sold since the brand's first VerticalMouse in 2002.

By the Comredix review desk · Updated November 13, 2026

Quality (40%)
7.8
Experience (25%)
8.0
Value (35%)
7.0

Evoluent calls its VerticalMouse the original vertical mouse and has sold it since 2002, and the VerticalMouse 4 Right Hand Wired (VM4R) is the classic version. Evoluent says it suits medium to large hands of 7.0 inches or more. It has 6 buttons with default functions for left click, forward, middle click, right click, back and horizontal scroll, and the Evoluent Mouse Manager software for Windows adds virtual buttons for up to 9 functions and lets you set different functions per program. The wired USB Type-A plug works in any USB-compatible system, so there is no battery to charge or replace. Evoluent also lists a left-hand wired model, a small right-hand model, wireless, Mac and Bluetooth versions. The drawbacks: the plug needs an adapter on USB-C only laptops, Mouse Manager does not run on macOS, and Bluetooth models have fixed buttons. We could not read a US price on Evoluent's store, so it ranks last on value until that check is done.

Who it is for

Windows users with large hands who want a wired vertical mouse

Price

See vendor pricing (USD check pending).

US price check pending. See the vendor pricing page.

Key features

  • Handshake grip, from the brand that has sold the VerticalMouse since 2002
  • Ideal for medium to large hands of 7.0 inches or more, per Evoluent
  • 6 buttons, including horizontal scroll, with up to 9 functions in Evoluent Mouse Manager for Windows
  • Wired USB Type-A plug that works in any USB-compatible system
  • Sold in right-hand, left-hand, small, wireless, Mac and Bluetooth versions

Strengths and weaknesses

  • Strength: Wired model needs no battery or charging
  • Strength: Left-hand wired version (VM4L) and a small right-hand version (VM4S)
  • Strength: Mouse Manager lets you set different button functions in different Windows programs
  • Weakness: We could not read a US price on Evoluent's store when we checked
  • Weakness: USB Type-A plug needs an adapter for USB-C only laptops
  • Weakness: Mouse Manager is not compatible with macOS, so buttons are fixed on a Mac

Key facts

  • Price: USD check pending
  • Type: Vertical, wired
  • Hand size: 7.0 inches or more
  • Buttons: 6
  • Connection: USB Type-A

Where it ranks

Evoluent VerticalMouse 4 is No. 9 in our Best Ergonomic Mice verdict.

Alternatives we scored

Visit evoluent.com · Questions or corrections: editorial@comredix.com