Similac 360 Total Care Infant Formula review

Similac 360 Total Care is the strongest alternative to Enfamil and the pick if HMOs are your main criterion. Abbott adds a blend of 5 HMO prebiotics that it describes as structurally identical to 5 of those found in breast milk, and says the formula is designed to support the immune system, brain development and digestive health. Similac calls itself the #1 infant formula brand fed in hospitals, which means many babies already know the taste when they come home. Milk ingredients come from cows not treated with rbST, and the formula is eligible for SNAP in select stores. On similac.com the powder is sold as a case of six 30.8 oz cans for $299.94, about $1.62 per ounce by our math, which is competitive but means a big first order. MySimilac Rewards adds up to $400 in offers. It is not organic and is not for babies with galactosemia.

Who it is for

parents who want the most HMOs in a mainstream formula

Price

$299.94 for a case of six 30.8 oz cans on similac.com, about $1.62 per ounce of powder.

Similac 360 Total Care Infant Formula Powder $299.94 30.8 oz Can / Case of 6
Quoted from the vendor pricing page on November 13, 2026.

Key features

• Blend of 5 HMO prebiotics structurally identical to 5 found in breast milk
• Designed to support the immune system, brain development and digestive health
• Milk from cows not treated with rbST, and ingredients not genetically engineered
• Eligible for SNAP benefits in select stores
• MySimilac Rewards offers up to $400 in benefits

Strengths and weaknesses

• Strength: 5 HMOs, the most listed by any formula on this list
• Strength: Similac says it is the #1 infant formula brand fed in hospitals, so many babies start on it
• Strength: Sister versions for sensitivity, organic and Irish dairy are on the same site
• Weakness: Similac.com sells this powder by the case of 6, so the first order is $299.94
• Weakness: Not for infants with galactosemia, as Similac notes
• Weakness: Not organic

Key facts

• HMOs: 5
• Can size: 30.8 oz (case of 6 on similac.com)
• Price per ounce: About $1.62 (our math from $299.94 for 184.8 oz)
• SNAP: Eligible in select stores
• Formats: Powder and ready-to-feed

Where it ranks

Similac 360 Total Care Infant Formula is No. 2 in our Best Baby Formula verdict.